Januskevicius Z I, Zabela P V, Zemaitytè D I, Liutkevich B I, Audickienè A P
Kardiologiia. 1976 Apr;16(4):20-6.
The rhythmographic technique was used to study the antiarrthythmic and chromotropic effect of intravenous injections of 10 mg of Obsidan (105 patients), of 10 mg of Isoptine (105 patients), and of oral administrations of 120 mg/day of Obsidan (160 patients) and Isoptine (128 patients). All patients demonstrated persistent extrasystole of different genesis against the background of the sinus rhythm. With intravenous injections the antiarrhythmic effect of Obsidan at rest did not differ from that of Isoptine. Under physical exercises Obsidan tended to display a more powerful negative bathmotropic effect. With the oral route of administration Obsidan was more effective both at rest, and under exercises. It produced a distinct negative chromotropic effect, while Isoptine displayed a biphasic effect. The results of automatic detection of the classes of the antiarrhythmic effect of Obsidan as judged by the dynamics of the sinus rhythm characteristics permit to suggest the possibility of using the later for an individual selection of the therapeutic means for extrasystole.
采用心律描记技术研究了静脉注射10毫克奥昔丹（105例患者）、10毫克异搏定（105例患者）以及口服每日120毫克奥昔丹（160例患者）和异搏定（128例患者）的抗心律失常和变时性效应。所有患者在窦性心律背景下均表现出不同起源的持续性期前收缩。静脉注射时，静息状态下奥昔丹的抗心律失常作用与异搏定无差异。在体育锻炼时，奥昔丹往往表现出更强的负性变力效应。口服给药时，奥昔丹在静息和运动时均更有效。它产生明显的负性变时性效应，而异搏定表现出双相效应。根据窦性心律特征的动态变化对奥昔丹抗心律失常作用类别进行自动检测的结果表明，有可能利用其为个体选择治疗期前收缩的治疗手段。
