Dragoje S, Tolnay M, Dalquen P, Probst A
Institute of Pathology, University Hospital, Basel, Switzerland.
Schweiz Arch Neurol Psychiatr (1985). 1995;146(6):277-80.
Herpes simplex encephalitis (HSE) could result from the reactivation of an endogenous latent herpes simplex virus (HSV) in sensory ganglia or in brain parenchyma. Virus replication and a new lytic virus cycle may be triggered by a wide variety of factors. One of these might be irradiation as suggested by experimental evidence obtained in mouse trigeminal ganglia. Here we report the occurrence of HSE in a 52 years old woman two months after brain irradiation (40 Gray in 20 fractions) and dexamethasone administration for a metastatic brain tumor. HSE has already been observed in a clinical context very similar to that reported here, suggesting that brain irradiation together with corticoid therapy may, in some rare patients, favour the occurrence of HSV reactivation and HSE.
单纯疱疹性脑炎（HSE）可能源于感觉神经节或脑实质内潜伏的单纯疱疹病毒（HSV）内源性激活。病毒复制和新的裂解病毒周期可能由多种因素触发。其中之一可能是如在小鼠三叉神经节中获得的实验证据所表明的辐射。在此，我们报告一名52岁女性在因转移性脑肿瘤接受脑部照射（20次分割，共40格雷）和地塞米松治疗两个月后发生了HSE。在与本文报道非常相似的临床背景下已经观察到HSE，这表明脑部照射联合皮质类固醇治疗在一些罕见患者中可能会促使HSV激活和HSE的发生。
