[Effect of hydrocortisone on mobilization and restoration of glycogen depot in the myocardium].

The mechanism of glycogen content changes in the heart muscle was studied in rat experiments by radio-isotope techniques 30, 60 min. and 3 hours following hydrocortisone administration. It was found that early after hydrocortisone administration (30 min.) the glycogen content in the myocardium decreases, and the incorporation of glucose-1-14C into glycogen increases, i.e. the process of mobilization and resynthesis of glycogen is activated. Proceeding from experiments with Propranolol the role of adrenergic factors in the mechanism of glycogen metabolism disorders in the heart muscle is discussed. Later, 3 hours following hydrocortisone administration, the concentration of glycogen and the incorporation of the radioactive label into the myocardial glycogen and blood glucose from the aminoacid glycine-1-14C is increased. The role of gluconeogenesis in the mechanism of corticosteroid regulation of glycogen metabolism in the heart muscle is discussed.