Meerson F Z, Saltykova V A
Kardiologiia. 1977 May;17(5):83-7.
The resistance of vessels in the hind limbs was determined under controlled perfusion in rats adapted to hypoxia at 2100 m altitude and in control animals at 200 m above the sea level. It was found that 15 days after the onset of adaptation the resistance of the resistive vessels decreases, after 30 days the degree of this decrease of resistance grows and it becomes statistically significant. The decrease of resistance in the resistive vessels of adapted animals persists after denervation of the extremity and depends on the reduction of the myogenic component of the vascular tonicity. This reduction of the myogenic component of the tonicity is accompanied by a reduction of the pressor reactions to asphyxia and addition of noradrenaline to the perfusate. The obtained data indicate that preliminary adaptation decelerates the development of experimentally induced hypertension.
在海拔2100米适应低氧环境的大鼠以及海平面以上200米的对照动物中，在受控灌注条件下测定后肢血管的阻力。结果发现，适应开始15天后，阻力血管的阻力降低，30天后这种阻力降低的程度增加且具有统计学意义。适应动物的阻力血管阻力降低在肢体去神经支配后仍然存在，并且取决于血管张力的肌源性成分的降低。张力的肌源性成分的这种降低伴随着对窒息的升压反应的降低以及向灌注液中添加去甲肾上腺素。所获得的数据表明，预先适应可减缓实验性诱导高血压的发展。
