Kashimoto S, Nakamura T, Furuya A, Nonaka A, Matsukawa T, Kumazawa T
Department of Anesthesiology, Yamanashi Medical University, Japan.
Resuscitation. 1995 Dec;30(3):269-73. doi: 10.1016/0300-9572(95)00889-6.
We have assessed the deleterious effects of methylmethacrylate (MMA) on cardiac function and metabolism in the isolated heart-lung preparation with or without volatile anesthetics. Wistar rats were prepared for the heart-lung model. They were randomly divided into 5 groups as follows. (1) Control (C) group. (2) Cement (M) group; they received MMA. (3) Halothane (H) group; they received MMA and 1% halothane. (4) Isoflurane (I) group; they received MMA and 1.5% isoflurane. (5) Sevoflurane (S) group; they received MMA and 2.5% sevoflurane. MMA 1000 micrograms/ml was administered 7 min after the start of perfusion except in the C group. At the end of the experimental period, the hearts were freeze-clamped and then myocardial high energy phosphates, lactate and glycogen were measured. Cardiac output in all groups but C group decreased significantly. PO2 of the perfusion blood in the M, H, I and S groups was significantly lower than that in the C group. Myocardial ATP in the M, H, I and S groups was significantly lower than that in the C group. ADP and AMP in the M, H, I and S groups were higher than those in the C group. There were no significant differences in lactate and glycogen levels between the 5 groups. MMA 1000 micrograms/ml is much higher than the blood level (0.05-31.89 micrograms/ml) which was reported in clinical patients who had femoral prosthesis. Therefore, the direct contribution of MMA itself to cardiac depression may be less than the other factors such as embolism in clinical situations. Volatile anesthetics did not influence the deleterious effects of MMA on cardiac function and metabolism.
我们评估了在有或没有挥发性麻醉剂的离体心肺制备模型中，甲基丙烯酸甲酯（MMA）对心脏功能和代谢的有害影响。将Wistar大鼠制备成心肺模型。它们被随机分为以下5组。（1）对照组（C组）。（2）骨水泥组（M组）；给予MMA。（3）氟烷组（H组）；给予MMA和1%氟烷。（4）异氟烷组（I组）；给予MMA和1.5%异氟烷。（5）七氟烷组（S组）；给予MMA和2.5%七氟烷。除C组外，在灌注开始7分钟后给予1000微克/毫升的MMA。实验期结束时，将心脏速冻夹闭，然后测定心肌高能磷酸盐、乳酸和糖原。除C组外，所有组的心输出量均显著降低。M组、H组、I组和S组灌注血的PO2显著低于C组。M组、H组、I组和S组的心肌ATP显著低于C组。M组、H组、I组和S组的ADP和AMP高于C组。5组之间的乳酸和糖原水平无显著差异。1000微克/毫升的MMA远高于报道的有股骨假体的临床患者的血药浓度（0.05 - 31.89微克/毫升）。因此，在临床情况下，MMA本身对心脏抑制的直接作用可能小于其他因素，如栓塞。挥发性麻醉剂并未影响MMA对心脏功能和代谢的有害作用。
