Kelly C, Rice J
Department of Computer Science and Statistics, University of Rhode Island, Kingston 02881, USA.
Math Biosci. 1996 Apr 1;133(1):85-109. doi: 10.1016/0025-5564(95)00083-6.
A new model of molecular evolution is introduced that allows for heterogeneous rates across the sequence positions. The development of this model was motivated by two issues: first, a number of studies have shown that the positions in a DNA sequence evolve at different rates, and second, it has been shown that not accounting for this heterogeneity can lead to biased estimates of evolutionary parameters. The authors generalize the Markovian model of molecular evolution to allow for heterogeneous rates and explore some of the consequences of such a model. In particular, they quantify the biases incurred by incorrectly assuming an equal-rate model and consider what can be learned about evolutionary parameters under a heterogeneous model.
引入了一种新的分子进化模型，该模型考虑了序列位置间的速率异质性。该模型的开发源于两个问题：其一，大量研究表明DNA序列中的位置以不同速率进化；其二，已有研究表明不考虑这种异质性会导致进化参数估计出现偏差。作者对分子进化的马尔可夫模型进行了推广，以考虑速率异质性，并探讨了这种模型的一些影响。具体而言，他们量化了错误假设等速率模型所产生的偏差，并考虑在异质性模型下可以了解到哪些关于进化参数的信息。
