Hatamochi A, Arakawa M, Mori K, Mori Y, Ueki H, Yoshioka H
Department of Dermatology, Kawasaki Medical School, Kurashiki, Japan.
J Dermatol Sci. 1996 Feb;11(2):97-103. doi: 10.1016/0923-1811(95)00425-4.
Type VI collagen gene expression in cutis laxa was studied by measuring messenger RNA (mRNA) and protein production levels in four fibroblast strains from patients with congenital cutis laxa and comparing them with those in fibroblasts obtained from age-matched healthy subjects. Levels of type VI collagen mRNA were increased in all cutis laxa fibroblast strains and the levels of alpha 1 (VI) and alpha 3 (VI) chain mRNAs increased in parallel. Increases in type VI collagen mRNAs correlated well with production levels of the corresponding proteins, as determined by immunological assay. These results suggest that increased type VI collagen gene expression is one of the characteristics of cutis laxa dermal fibroblasts and that this abnormality may be related to the skin changes in cutis laxa.
通过测量先天性皮肤松弛症患者的四个成纤维细胞株中信使核糖核酸（mRNA）和蛋白质产生水平，并将其与从年龄匹配的健康受试者获得的成纤维细胞中的水平进行比较，研究了皮肤松弛症中VI型胶原基因的表达。所有皮肤松弛症成纤维细胞株中VI型胶原mRNA水平均升高，α1（VI）和α3（VI）链mRNA水平平行升高。如通过免疫测定所确定的，VI型胶原mRNA的增加与相应蛋白质的产生水平密切相关。这些结果表明，VI型胶原基因表达增加是皮肤松弛症真皮成纤维细胞的特征之一，并且这种异常可能与皮肤松弛症中的皮肤变化有关。
