Ognjanović B, Zikić R V, Stajn A, Saicić Z S, Kostić M M, Petrović V M
Faculty of Science, University of Kragujevac, Serbia, Yugoslavia.
Physiol Res. 1995;44(5):293-300.
Total superoxide dismutase (total SOD), copper zinc containing superoxide dismutase (CuZn SOD), and manganese superoxide dismutase (Mn SOD), catalase (CAT), glutathione peroxidase (GSH-Px), and glutathione-S-transferase (GST) activities as well as ascorbic acid (AsA), and vitamin E (vit E) concentrations were analysed in the liver of rats exposed to cadmium (15 mg Cd/day/kg), selenium (7 micrograms Se/day/kg), and to cadmium+selenium (15 mg Cd + 7 micrograms Se/day/kg), and in control animals. Cadmium caused a decrease of total SOD, Mn SOD, CAT and GSH-Px but an increase of GST activity in the liver of rats. Contrary to cadmium, selenium caused a significant increase of the activity of these enzymes except for GSH-Px. By concomitant exposure to both cadmium and selenium, the toxic effects of cadmium on the activity of mentioned enzymes we abolished. In all exposed groups, the activity of enzyme glutathione-S-transferase was enhanced, indicating its increased role in prevention of lipid peroxidation. Cadmium decreased the concentration of AsA and increased the concentration of vitamin E in the liver, while selenium increased the concentration of both vitamins. However, by concomitant administration of cadmium and selenium, these changes were diminished and tended to reach control values.
对暴露于镉（15毫克镉/天/千克）、硒（7微克硒/天/千克）以及镉+硒（15毫克镉+7微克硒/天/千克）的大鼠肝脏和对照动物肝脏中的总超氧化物歧化酶（总SOD）、含铜锌超氧化物歧化酶（CuZn SOD）、锰超氧化物歧化酶（Mn SOD）、过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GSH-Px）、谷胱甘肽-S-转移酶（GST）活性以及抗坏血酸（AsA）和维生素E（维生素E）浓度进行了分析。镉导致大鼠肝脏中总SOD、Mn SOD、CAT和GSH-Px活性降低，但GST活性增加。与镉相反，硒导致除GSH-Px外这些酶的活性显著增加。通过同时暴露于镉和硒，镉对上述酶活性的毒性作用被消除。在所有暴露组中，谷胱甘肽-S-转移酶的活性增强，表明其在预防脂质过氧化中的作用增加。镉降低了肝脏中AsA的浓度并增加了维生素E的浓度，而硒增加了两种维生素的浓度。然而，通过同时给予镉和硒，这些变化减弱并趋于达到对照值。
