Dupouey P, Jacque C, Bourre J M, Cesselin F, Privat A, Baumann N
Neurosci Lett. 1979 Apr;12(1):113-8. doi: 10.1016/0304-3940(79)91490-3.
The myelin-deficient mutant Shiverer (Shi/Shi) lacks basic protein (MBP) in the myelin of its central nervous system (CNS). Less than 3% of the normal content in MBP is present in a brain extract of Shi/Shi as determined by radioimmunoassay. Indirect immunofluorescence is negative when using specific anti-MBP serum. The importance of Shi/Shi (as compared to other hypomelinating mutants) stems from the specificity of this genetic lesion, i.e. the lack of basic protein.
髓磷脂缺陷型突变体颤抖小鼠（Shi/Shi）中枢神经系统（CNS）的髓磷脂中缺乏碱性蛋白（MBP）。通过放射免疫测定法测定，Shi/Shi脑提取物中的MBP含量不到正常含量的3%。使用特异性抗MBP血清时，间接免疫荧光呈阴性。Shi/Shi（与其他髓鞘形成减少的突变体相比）的重要性源于这种基因损伤的特异性，即缺乏碱性蛋白。
