治疗胃肠道癌的新型全身用药
New systemic drugs in the treatment of gastrointestinal cancer.
作者信息
Ogawa M
机构信息
Aichi Cancer Center, Nagoya, Japan.
出版信息
Curr Opin Oncol. 1996 Jul;8(4):317-20. doi: 10.1097/00001622-199607000-00009.
Abstract
Paclitaxel has shown a significant activity on esophageal cancer in a phase II trial. Irinotecan has established the single-agent efficacy on both gastric and colorectal cancer. Docetaxel has attained a significant activity on advanced gastric cancer and a 29% response rate on pancreatic cancer in a phase II trial. Tomudex has shown comparable activity to leucovorin and 5-fluorouracil in colorectal cancer.
摘要
在一项II期试验中，紫杉醇已显示出对食管癌有显著活性。伊立替康已证实对胃癌和结直肠癌均有单药疗效。多西他赛在一项II期试验中已显示出对晚期胃癌有显著活性，对胰腺癌的缓解率为29%。在结直肠癌中，拓扑替康已显示出与亚叶酸钙和5-氟尿嘧啶相当的活性。
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