Collins P, Beale C M, Rosano G M
Department of Cardiac Medicine, National Heart and Lung Institute, London, U.K.
Eur Heart J. 1996 Aug;17 Suppl D:27-31. doi: 10.1093/eurheartj/17.suppl_d.27.
This paper reviews the evidence for calcium-antagonist properties of oestrogen which may offer long-term protective effects on the cardiovascular system in postmenopausal women. Oestrogen has already been shown to have a beneficial effect on cholesterol metabolism and deposition, thereby inhibiting the formation of atherosclerotic plaque and coronary atheroma. Calcium antagonism, resulting in both acute and chronic modulation of coronary and peripheral vasomotion, is another mechanism by which oestrogens may provide cardiovascular benefits to women, including those with existing cardiovascular disease.
本文综述了雌激素具有钙拮抗剂特性的证据，这些特性可能对绝经后女性的心血管系统产生长期保护作用。雌激素已被证明对胆固醇代谢和沉积具有有益作用，从而抑制动脉粥样硬化斑块和冠状动脉粥样瘤的形成。钙拮抗作用可导致冠状动脉和外周血管运动的急性和慢性调节，这是雌激素可能为女性（包括患有现有心血管疾病的女性）提供心血管益处的另一种机制。
