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Effects of hyperammonemia on brain protein kinase C substrates.

作者信息

Grau E, Marcaida G, Montoliu C, Miñana M D, Grisolía S, Felipo V

机构信息

Instituto de Investigaciones Citologicas de la Fundacion Valenciana de Investigaciones Biomedicas, Spain.

出版信息

Metab Brain Dis. 1996 Sep;11(3):205-16. doi: 10.1007/BF02237958.

DOI:10.1007/BF02237958
PMID:8869941
Abstract
摘要

相似文献

1
Effects of hyperammonemia on brain protein kinase C substrates.
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2
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3
Brain metabolism in encephalopathy caused by hyperammonemia.高氨血症所致脑病中的脑代谢
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Effects of acute hyperammonemia in vivo on oxidative metabolism in nonsynaptic rat brain mitochondria.急性高氨血症对大鼠非突触性脑线粒体氧化代谢的体内影响。
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Differential modulation of protein kinase C by bryostatin 1 and phorbol ester.苔藓抑素1和佛波酯对蛋白激酶C的差异调节
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Chronic exposure to ammonia induces isoform-selective alterations in the intracellular distribution and NMDA receptor-mediated translocation of protein kinase C in cerebellar neurons in culture.长期暴露于氨会诱导培养的小脑神经元中蛋白激酶C的细胞内分布和NMDA受体介导的易位发生亚型选择性改变。
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Hyperammonemia induces brain tubulin.高氨血症会诱导脑微管蛋白。
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Low myo-inositol and high glutamine levels in brain are associated with neuropsychological deterioration after induced hyperammonemia.大脑中肌醇水平低和谷氨酰胺水平高与诱导性高氨血症后的神经心理衰退有关。
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引用本文的文献

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Possible Association Between DHEA and PKCε in Hepatic Encephalopathy Amelioration: A Pilot Study.脱氢表雄酮与蛋白激酶Cε在改善肝性脑病中的可能关联：一项初步研究。
Front Vet Sci. 2021 Sep 28;8:695375. doi: 10.3389/fvets.2021.695375. eCollection 2021.
2
Hyperammonemia impairs NMDA receptor-dependent long-term potentiation in the CA1 of rat hippocampus in vitro.高氨血症会损害体外培养的大鼠海马体CA1区中依赖N-甲基-D-天冬氨酸（NMDA）受体的长时程增强效应。
Neurochem Res. 2000 Apr;25(4):437-41. doi: 10.1023/a:1007547622844.

本文引用的文献

1
Acute metabolic effects of ammonia in mouse brain.鼠脑氨的急性代谢效应。
Neurochem Res. 1977 Dec;2(6):639-55. doi: 10.1007/BF00963777.
2
The cerebral and peripheral uptake of ammonia in liver disease with an hypothesis for the mechanism of hepatic coma.肝脏疾病中大脑和外周对氨的摄取以及肝昏迷机制的一种假说
J Clin Invest. 1955 Apr;34(4):622-8. doi: 10.1172/JCI103111.
3
Ammonia prevents activation of NMDA receptors by glutamate in rat cerebellar neuronal cultures.氨可防止大鼠小脑神经元培养物中谷氨酸对N-甲基-D-天冬氨酸受体的激活。
Eur J Neurosci. 1995 Dec 1;7(12):2389-96. doi: 10.1111/j.1460-9568.1995.tb01036.x.
4
Loss of [3H]MK801 binding sites in brain in congenital ornithine transcarbamylase deficiency.先天性鸟氨酸转氨甲酰酶缺乏症患者大脑中[3H]MK801结合位点的丧失。
Metab Brain Dis. 1995 Sep;10(3):249-55. doi: 10.1007/BF02081030.
5
Na+,K(+)-ATPase activities are increased in brain in both congenital and acquired hyperammonemic syndromes.在先天性和后天性高氨血症综合征中，大脑中的钠钾ATP酶活性均会升高。
Neurosci Lett. 1995 Sep 8;197(2):89-92. doi: 10.1016/0304-3940(95)11906-d.
6
Hyperammonemia decreases protein-kinase-C-dependent phosphorylation of microtubule-associated protein 2 and increases its binding to tubulin.
Eur J Biochem. 1993 May 15;214(1):243-9. doi: 10.1111/j.1432-1033.1993.tb17917.x.
7
Effect of reducing brain glutamine synthesis on metabolic symptoms of hepatic encephalopathy.降低脑谷氨酰胺合成对肝性脑病代谢症状的影响。
J Neurochem. 1993 Mar;60(3):1000-6. doi: 10.1111/j.1471-4159.1993.tb03247.x.
8
Chronic hyperammonemia prevents changes in brain energy and ammonia metabolites induced by acute ammonium intoxication.慢性高氨血症可防止急性铵中毒引起的脑能量和氨代谢产物的变化。
Biochim Biophys Acta. 1993 Jan 22;1180(3):321-6. doi: 10.1016/0925-4439(93)90057-8.
9
Enhanced endogenous ornithine concentrations protect against tonic seizures and coma in acute ammonia intoxication.内源性鸟氨酸浓度升高可预防急性氨中毒时的强直性惊厥和昏迷。
Pharmacol Toxicol. 1993 Feb;72(2):116-23. doi: 10.1111/j.1600-0773.1993.tb00301.x.
10
Brain ATP depletion induced by acute ammonia intoxication in rats is mediated by activation of the NMDA receptor and Na+,K(+)-ATPase.大鼠急性氨中毒诱导的脑ATP耗竭是由NMDA受体和Na +，K（+）-ATP酶的激活介导的。
J Neurochem. 1994 Dec;63(6):2172-8. doi: 10.1046/j.1471-4159.1994.63062172.x.