Effects of hyperammonemia on brain protein kinase C substrates.

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作者信息

Grau E, Marcaida G, Montoliu C, Miñana M D, Grisolía S, Felipo V

机构信息

Instituto de Investigaciones Citologicas de la Fundacion Valenciana de Investigaciones Biomedicas, Spain.

出版信息

Metab Brain Dis. 1996 Sep;11(3):205-16. doi: 10.1007/BF02237958.

DOI:10.1007/BF02237958

PMID:8869941

Abstract

摘要

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本文引用的文献

Acute metabolic effects of ammonia in mouse brain.鼠脑氨的急性代谢效应。

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The cerebral and peripheral uptake of ammonia in liver disease with an hypothesis for the mechanism of hepatic coma.肝脏疾病中大脑和外周对氨的摄取以及肝昏迷机制的一种假说

J Clin Invest. 1955 Apr;34(4):622-8. doi: 10.1172/JCI103111.

Ammonia prevents activation of NMDA receptors by glutamate in rat cerebellar neuronal cultures.氨可防止大鼠小脑神经元培养物中谷氨酸对N-甲基-D-天冬氨酸受体的激活。

Eur J Neurosci. 1995 Dec 1;7(12):2389-96. doi: 10.1111/j.1460-9568.1995.tb01036.x.

Loss of [3H]MK801 binding sites in brain in congenital ornithine transcarbamylase deficiency.先天性鸟氨酸转氨甲酰酶缺乏症患者大脑中[3H]MK801结合位点的丧失。

Metab Brain Dis. 1995 Sep;10(3):249-55. doi: 10.1007/BF02081030.

Na+,K(+)-ATPase activities are increased in brain in both congenital and acquired hyperammonemic syndromes.在先天性和后天性高氨血症综合征中，大脑中的钠钾ATP酶活性均会升高。

Neurosci Lett. 1995 Sep 8;197(2):89-92. doi: 10.1016/0304-3940(95)11906-d.

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Eur J Biochem. 1993 May 15;214(1):243-9. doi: 10.1111/j.1432-1033.1993.tb17917.x.

Effect of reducing brain glutamine synthesis on metabolic symptoms of hepatic encephalopathy.降低脑谷氨酰胺合成对肝性脑病代谢症状的影响。

J Neurochem. 1993 Mar;60(3):1000-6. doi: 10.1111/j.1471-4159.1993.tb03247.x.

Chronic hyperammonemia prevents changes in brain energy and ammonia metabolites induced by acute ammonium intoxication.慢性高氨血症可防止急性铵中毒引起的脑能量和氨代谢产物的变化。

Biochim Biophys Acta. 1993 Jan 22;1180(3):321-6. doi: 10.1016/0925-4439(93)90057-8.

Enhanced endogenous ornithine concentrations protect against tonic seizures and coma in acute ammonia intoxication.内源性鸟氨酸浓度升高可预防急性氨中毒时的强直性惊厥和昏迷。

Pharmacol Toxicol. 1993 Feb;72(2):116-23. doi: 10.1111/j.1600-0773.1993.tb00301.x.

Brain ATP depletion induced by acute ammonia intoxication in rats is mediated by activation of the NMDA receptor and Na+,K(+)-ATPase.大鼠急性氨中毒诱导的脑ATP耗竭是由NMDA受体和Na +，K（+）-ATP酶的激活介导的。

J Neurochem. 1994 Dec;63(6):2172-8. doi: 10.1046/j.1471-4159.1994.63062172.x.

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