Naganuma H, Ohtani H, Sayama J, Sakai N, Taira Y, Shibuya D, Miyazaki A, Sakurada H
Department of Pathology, Sendai City Hospital, Japan.
Pathol Int. 1996 Jun;46(6):462-6. doi: 10.1111/j.1440-1827.1996.tb03638.x.
A 78-year-old man presented with an esophageal polyp that was confirmed by immunohistochemistry and electron microscopy to be malignant fibrous histiocytoma. The tumor was comprised of a proliferation of spindle-shaped cells admixed with bizarre giant cells. These tumor cells were immunoreactive for smooth muscle actin, vimentin, alpha-1-anti-chymotrypsin and CD68. Electron microscopic examination revealed the myofibroblastic and histiocytic features of the tumor cells. No elements of epithelial or myogenic differentiation were found in the tumor. Malignant fibrous histiocytoma of the esophagus is extremely rare, with 10 cases being documented so far in the literature. The differential diagnosis of pleomorphic tumors of the esophagus is discussed.
一名78岁男性因食管息肉就诊，经免疫组织化学和电子显微镜检查确诊为恶性纤维组织细胞瘤。肿瘤由梭形细胞增生并伴有奇异巨细胞组成。这些肿瘤细胞对平滑肌肌动蛋白、波形蛋白、α-1-抗胰凝乳蛋白酶和CD68呈免疫反应性。电子显微镜检查显示肿瘤细胞具有肌成纤维细胞和组织细胞特征。肿瘤中未发现上皮或肌源性分化成分。食管恶性纤维组织细胞瘤极为罕见，迄今为止文献中仅记载了10例。本文讨论了食管多形性肿瘤的鉴别诊断。
