Erşahin Y, Demirtaş E, Mutluer S, Tosun A R, Saydam S
Department of Neurosurgery, Ege University Faculty of Medicine, Izmir, Turkey.
Pediatr Neurosurg. 1996;24(3):155-9. doi: 10.1159/000121033.
The unified theory, proposed by Pang et al., explains the embryogenetic mechanisms of all variants of split cord malformations (SCMs). All SCMs originate from one basic error occurring around the time when the primitive neurenteric canal closes. The basic error is the formation of an accessory neurenteric canal between the yolk sac and amnion which is subsequently invested with mesenchyme to form an endomesenchymal tract that splits the notochord and neural plate. Three cases of SCMs which support this unified theory are presented. A 3-month-old girl had a combination of both types of SCMs at the level of T11. The 2nd case, a 2-week-old girl, had type-II SCM associated with a thickened filum terminale, lipomyelomeningocele and ectopic renal tissue within lipoma. A lipomatous tract extending from a subcutaneous lipoma to the intradural fibrous septum contained lymphoid tissues and tubular epithelia in a 3-month-old boy with a type-II SCM. These 3 cases support the unified theory.
庞等人提出的统一理论解释了脊髓纵裂畸形（SCMs）所有变体的胚胎发生机制。所有SCMs均源于原始神经肠管闭合前后发生的一个基本错误。基本错误是在卵黄囊和羊膜之间形成一个副神经肠管，随后该副神经肠管被间充质覆盖，形成一个将脊索和神经板分开的内胚层间充质束。本文介绍了支持这一统一理论的3例SCMs病例。一名3个月大的女孩在T11水平同时存在两种类型的SCMs。第二例是一名2周大的女孩，患有II型SCM，伴有终丝增厚、脂肪脊髓脊膜膨出和脂肪瘤内的异位肾组织。在一名患有II型SCM的3个月大男孩中，一条从皮下脂肪瘤延伸至硬膜内纤维间隔的脂肪瘤束包含淋巴组织和管状上皮。这3例病例支持该统一理论。
