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急性肝坏死合并脂肪肝时的致命性脂肪栓塞

Fatal fat embolism in acute hepatic necrosis with associated fatty liver.

作者信息

Schulz F, Trübner K, Hildebrand E

机构信息

Gerichtsärztlicher Dienst, Behörde für Arbeit, Gesundheit, und Soziales, Hamburg, Germany.

出版信息

Am J Forensic Med Pathol. 1996 Sep;17(3):264-8. doi: 10.1097/00000433-199609000-00016.

Abstract

We report two cases of generalized nonviolent hepatogenic fat embolism. A 63-year-old woman was sent to the hospital with suspected mushroom poisoning. Shock symptoms occurred quickly and could not be treated effectively; the patient died 24 h after admission. Postmortem examination showed acute yellow dystrophy of the liver with a severe preexisting fatty liver. Any intoxication including Amanita phalloides could be excluded. In all probability, a fulminant viral hepatitis caused liver dystrophy, and the decay of the fatty liver cells led to generalized fat embolism as the cause of death. The second patient, a 46-year-old man, was reported to have suffered from an acute illness while in prison and died after having been transferred to the local hospital. Histological examinations showed an acute liver dystrophy probably caused by fulminant viral hepatitis with fatty degeneration. In this case, the cause of death was also found to be generalized fat embolism.

摘要

我们报告两例全身性非暴力性肝源性脂肪栓塞病例。一名63岁女性因疑似蘑菇中毒被送往医院。休克症状迅速出现且无法有效治疗;患者入院后24小时死亡。尸检显示肝脏急性黄色萎缩,伴有严重的既往脂肪肝。可排除包括毒鹅膏在内的任何中毒情况。很可能是暴发性病毒性肝炎导致肝脏萎缩,脂肪肝细胞的坏死导致全身性脂肪栓塞成为死因。第二例患者是一名46岁男性,据报告在狱中患急性病,转至当地医院后死亡。组织学检查显示急性肝脏萎缩可能由伴有脂肪变性的暴发性病毒性肝炎引起。在该病例中,死因也被发现是全身性脂肪栓塞。

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