成年叙利亚金仓鼠经腹腔注射二乙基亚硝胺后精原细胞DNA中O6-乙基鸟嘌呤的形成。
Formation of O6-ethylguanine in spermatogonial DNA of adult Syrian golden hamster by intraperitoneal injection of diethylnitrosamine.
作者信息
Kamino K, Seiler F, Emura M, Thomale J, Rajewsky M F, Mohr U
机构信息
Institute of Experimental Pathology, Hannover Medical School, Germany.
出版信息
Exp Toxicol Pathol. 1995 Dec;47(6):443-5. doi: 10.1016/S0940-2993(11)80324-6.
17-Week-old Syrian golden hamsters received a single intraperitoneal injection of diethylnitrosamine (DEN) at a dose of 100 mg/kg body weight. The DNA alkylation product O6-ethylguanine was formed in the spermatogonia. The data demonstrate that DEN can pass the blood-testis barrier and be metabolized in the spermatogonia to yield an alkylating derivative or that externally activated metabolites themselves can pass the barrier.
17周龄的叙利亚金黄地鼠接受了一次腹腔注射，剂量为100毫克/千克体重的二乙基亚硝胺（DEN）。DNA烷基化产物O6-乙基鸟嘌呤在精原细胞中形成。数据表明，DEN可以穿过血睾屏障并在精原细胞中代谢产生烷基化衍生物，或者外部激活的代谢产物本身可以穿过该屏障。
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