Smith N C, Ovington K S
Institut für Parasitologie, Universität Zürich, Switzerland.
Immunol Cell Biol. 1996 Aug;74(4):346-8. doi: 10.1038/icb.1996.61.
Infection of animals with species of Eimeria induces a hyper-reactivity to endotoxin as manifest by a greatly increased capacity of infected animals to produce TNF in response to LPS in vivo compared with uninfected animals. This finding indicates priming for hyperactivation of macrophages by Eimeria infection and raises the possibility that non-specific triggering of macrophages by agents such as Bacille Calmette-Guerin (BCG), zymosan or Coxiella burnetti extract may be a simple means of control for coccidiosis. However, all of these agents enhanced oocyst excretion in mice, rats or chickens infected with Eimeria vermiformis, Eimeria nieschulzi or Eimeria tenella, respectively, without affecting the patent period.
艾美耳球虫属物种感染动物会诱导对内毒素的高反应性，表现为与未感染动物相比，感染动物体内对脂多糖（LPS）产生肿瘤坏死因子（TNF）的能力大大增强。这一发现表明艾美耳球虫感染引发巨噬细胞过度活化，并增加了一种可能性，即诸如卡介苗（BCG）、酵母聚糖或伯氏考克斯氏体提取物等物质对巨噬细胞的非特异性触发可能是控制球虫病的一种简单方法。然而，所有这些物质分别增强了感染蠕形艾美耳球虫、尼氏艾美耳球虫或柔嫩艾美耳球虫的小鼠、大鼠或鸡的卵囊排泄，且不影响感染期。
