Cox J E
Department of Psychology, University of Alabama, Birmingham 35294, USA.
Physiol Behav. 1996 Sep;60(3):1023-6. doi: 10.1016/0031-9384(96)00153-9.
Because inflation of a pyloric cuff during feeding blocks gastric emptying and increases gastric distention, this device was used to test the hypothesis of synergism between gastric distention and cholecystokinin octapeptide (CCK-8) in reducing intake. Adult, male Sprague-Dawley rat were allowed 20-min access to 30% sucrose, with or without inflation of pyloric cuffs, after intraperitoneal injection of saline or 1, 2, or 4 micrograms/kg CCK-8. Cuff inflation resulted in large increases in gastric volume at the end of feeding tests. However, this manipulation failed to enhance the effectiveness of any dose of CCK-8. In fact, data analyses revealed trends suggestive of decreased effectiveness of the two lowest doses under these conditions. The effect of 4 micrograms/kg CCK-8 was almost identical in tests with and without cuff inflation. These results are contrary to the prediction of greater potency of CCK-8 resulting from increased gastric distention.
由于喂食期间幽门套囊充气会阻碍胃排空并增加胃扩张，因此使用该装置来检验胃扩张与八肽胆囊收缩素（CCK - 8）在减少摄入量方面协同作用的假设。成年雄性斯普拉格 - 道利大鼠在腹腔注射生理盐水或1、2或4微克/千克CCK - 8后，有20分钟时间可以摄取30%的蔗糖，同时幽门套囊充气或不充气。在喂食试验结束时，套囊充气导致胃容量大幅增加。然而，这种操作未能增强任何剂量CCK - 8的效果。事实上，数据分析显示，在这些条件下，有迹象表明两种最低剂量的效果有所降低。在有和没有套囊充气的试验中，4微克/千克CCK - 8的效果几乎相同。这些结果与胃扩张导致CCK - 8效力增强的预测相反。
