Takei N, Lewis S, Jones P, Harvey I, Murray R M
Dept. of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, United Kingdom.
Schizophr Bull. 1996;22(3):521-34. doi: 10.1093/schbul/22.3.521.
Several epidemiological studies have suggested that maternal exposure to influenza during midgestation is a risk factor for schizophrenia. In exploring the possible pathogenic mechanism, we examined the relationship between computed tomography structural brain measures in 83 schizophrenia patients and 113 controls and also their risk of maternal exposure to influenza. Four brain measures of the cerebrospinal fluid (CSF) spaces (lateral ventricle, maximum third ventricle, sulcal fluid, and sylvian fissure) were investigated in relation to the risk exposure level. In schizophrenia patients, these measures, in particular sylvian fissures, were found to increase with higher levels of risk exposure to influenza during the susceptible period (i.e., midgestation); no such effect was found in controls. These results indicate that risk for midgestational influenza exposure is associated with generalized enlargement of the CSF spaces, especially in the region of the temporal lobe. The findings suggest that certain morphological abnormalities of the brain frequently reported in schizophrenia patients may be partly attributable to antenatal exposure to influenza.
多项流行病学研究表明，孕期中期母亲感染流感是精神分裂症的一个风险因素。在探究可能的致病机制时，我们检查了83名精神分裂症患者和113名对照者的脑部计算机断层扫描结构测量值与其母亲孕期感染流感的风险之间的关系。针对脑脊液（CSF）间隙的四项脑部测量值（侧脑室、最大第三脑室、脑沟液和外侧裂）与风险暴露水平的关系进行了研究。在精神分裂症患者中，这些测量值，尤其是外侧裂，在易感期（即孕期中期）随着流感风险暴露水平的升高而增加；在对照者中未发现此类影响。这些结果表明，孕期中期感染流感的风险与脑脊液间隙普遍增大有关，尤其是在颞叶区域。研究结果表明，精神分裂症患者中经常报告的某些脑部形态异常可能部分归因于产前感染流感。
