Salomon S, Steinbrüchel D, Nielsen B, Kemp E
Laboratory of Nephropathology, Odense University Hospital, Denmark.
Urol Res. 1996;24(4):211-6. doi: 10.1007/BF00295894.
Hamster to rat kidney transplantation has only recently been introduced as model of concordant xenografting. The kidney model offers unique possibilities for studying both immunological and functional aspects of xenografts as opposed to the widely used heterotopic heart model. This article provides a detailed description of surgical technique as well as data on functional outcome and complications. The renal artery with a small segment of the aorta is sutured end-to-side to the abdominal aorta of the recipient, and the renal vein is anastomosed end-to-side to the inferior vena cava. The urinary system is reconstructed by bladder-to-bladder anastomosis. Xenografts will maintain close to normal serum-creatinine levels for 2-3 days, after which they are rejected. Complications occurred in 22% of xenografts. Postrenal obstruction due to severe hematuria or ureter stenosis was the most frequent problem encountered.
仓鼠到大鼠的肾脏移植作为一种协调性异种移植模型，直到最近才被引入。与广泛使用的异位心脏模型不同，肾脏模型为研究异种移植的免疫学和功能方面提供了独特的可能性。本文详细描述了手术技术以及功能结果和并发症的数据。带有一小段主动脉的肾动脉端侧缝合到受体的腹主动脉上，肾静脉端侧吻合到下腔静脉。泌尿系统通过膀胱对膀胱吻合进行重建。异种移植在2 - 3天内将维持接近正常的血清肌酐水平，之后被排斥。22%的异种移植发生了并发症。由于严重血尿或输尿管狭窄导致的肾后梗阻是最常遇到的问题。
