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[真性红细胞增多症相关坏疽性脓皮病期间的免疫缺陷]

[Immune deficiences during pyoderma gangrenosum associated with a polycythemia vera].

作者信息

Deschamps P, Leroy D, Dresch C, Michel M

出版信息

Nouv Presse Med. 1977 Jun 25;6(26):2339-41.

PMID:887420
Abstract

A deficiency in cellular immunity was demonstrated in a patient suffering from polycythaemia rubra vera in the myelofibrosis stage. Intradermal reactions to classical antigens (candidine, trichophytine, streptokinase, streptodornase, tuberculine) were negative, as was the di-nitrofluorobenzene test. However, the T lymphocyte count was normal. There was no disturbance in humoral immunity. Phagocytosis was normal but leucocyte migration, studied in vitro, was nil. The possibility of an intrinsic abnormality in the polynuclear neutrophil is evoked.

摘要

一名处于骨髓纤维化阶段的真性红细胞增多症患者被证实存在细胞免疫缺陷。对经典抗原(念珠菌素、癣菌素、链激酶、链道酶、结核菌素)的皮内反应呈阴性,二硝基氟苯试验结果也是如此。然而,T淋巴细胞计数正常。体液免疫没有紊乱。吞噬作用正常,但体外研究的白细胞迁移为零。由此引发了多核中性粒细胞存在内在异常的可能性。

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