Légrádi G, Rand W M, Hitz S, Nillni E A, Jackson I M, Lechan R M
Department of Medicine, New England Medical Center Hospitals, Boston, MA 02111, USA.
Brain Res. 1996 Aug 5;729(1):10-19. doi: 10.1016/s0006-8993(96)00210-7.
The midbrain periaqueductal gray matter (PAG) has a critical role in the modulation of behavioral and autonomic manifestations of the opiate withdrawal syndrome. We report a nearly 5-fold increase in proTRH gene expression in neurons of the ventrolateral column of the PAG following naltrexone precipitated morphine withdrawal. The accumulation of immunoreactive proTRH-derived peptides, but not the mature TRH tripeptide was concomitantly observed in these cells. These findings indicate that proTRH-derived peptides synthesized in neurons of the ventrolateral PAG may function as modifiers of opiate withdrawal responses.
中脑导水管周围灰质（PAG）在阿片类药物戒断综合征的行为和自主神经表现的调节中起关键作用。我们报告，在纳曲酮诱发吗啡戒断后，PAG腹外侧柱神经元中proTRH基因表达增加了近5倍。在这些细胞中同时观察到免疫反应性proTRH衍生肽的积累，但未观察到成熟的TRH三肽的积累。这些发现表明，在腹外侧PAG神经元中合成的proTRH衍生肽可能作为阿片类药物戒断反应的调节剂发挥作用。
