Tan W Y, Zhang J H
Department of Mathematical Sciences, University of Memphis, TN 38152, USA.
Environ Health Perspect. 1996 Aug;104(8):872-7. doi: 10.1289/ehp.96104872.
By using a two stage model of carcinogenesis, we generated Monte Carlo studies to assess the efficiency and robustness of the 3-poly test for animal carcinogenicity experiments. The Monte Carlo results indicate that the 3-poly test is quite powerful for detecting the carcinogenic effects of complete carcinogens, moderate promoters, and initiators with moderate or large effect, but, in some cases, it is less powerful for weak initiators or weak promoters. As expected, the 3-poly test is insensitive to the toxicity of many agents.
通过使用两阶段致癌模型，我们进行了蒙特卡罗研究，以评估动物致癌性实验中三多聚体试验的效率和稳健性。蒙特卡罗结果表明，三多聚体试验在检测完全致癌物、中度促癌剂以及具有中度或较大效应的引发剂的致癌作用方面相当有效，但在某些情况下，对于弱引发剂或弱促癌剂的检测效力较低。正如预期的那样，三多聚体试验对许多试剂的毒性不敏感。
