Portier C J, Hedges J C, Hoel D G
Cancer Res. 1986 Sep;46(9):4372-8.
This paper models general survival and the distribution of tumor onset times for various tumors in the data base of control animals developed by the National Toxicology Program. For general survival, a modified Weibull model is shown to give an adequate fit for both Fischer 344 rats and C57BL/6 X C3H F1, mice. In addition, data from control animals in a lifetime study of asbestos are used to support the extension of these survival curves beyond 2 years in Fischer rats. The distributions of tumor onset times are modeled using a two-parameter Weibull model. For many common tumor types, this model yielded a very good fit to the data. Finally, a summary measure of the contribution of a tumor to mortality is given.
本文对由国家毒理学计划建立的对照动物数据库中各种肿瘤的总体生存率和肿瘤发病时间分布进行了建模。对于总体生存率，一个修正的威布尔模型被证明对费舍尔344大鼠和C57BL/6×C3H F1小鼠都有足够的拟合度。此外，石棉终生研究中对照动物的数据被用来支持费舍尔大鼠这些生存曲线超过2年的延伸。肿瘤发病时间的分布使用双参数威布尔模型进行建模。对于许多常见的肿瘤类型，该模型对数据有很好的拟合度。最后，给出了肿瘤对死亡率贡献的一个汇总指标。
