前列腺癌前体中的神经内分泌分化。
Neuroendocrine differentiation in the precursors of prostate cancer.
作者信息
di Sant' Agnese P A
机构信息
University of Rochester Medical Center, NY 14642, USA.
出版信息
Eur Urol. 1996;30(2):185-90. doi: 10.1159/000474168.
OBJECTIVES
To review neuroendocrine differentiation in the precursors of prostatic carcinoma (prostatic intraepithelial neoplasia).
METHODS
Background information is given on the prostatic neuroendocrine cell and neuroendocrine differentiation in prostatic carcinoma. Neuroendocrine differentiation in prostatic intraepithelial neoplasia is reviewed.
RESULTS
Neuroendocrine differentiation occurs in prostatic intraepithelial neoplasia and is intermediate in degree between normal (which has the most cells with neuroendocrine differentiation) and carcinoma.
CONCLUSION
Neuroendocrine differentiation in the precursors of prostatic carcinoma may play a role in the pathogenesis of cancer but is speculative at this time. Methods to better assess neuroendocrine differentiation are needed.
目的
回顾前列腺癌前体（前列腺上皮内瘤变）中的神经内分泌分化。
方法
给出关于前列腺神经内分泌细胞及前列腺癌中神经内分泌分化的背景信息。对前列腺上皮内瘤变中的神经内分泌分化进行回顾。
结果
神经内分泌分化存在于前列腺上皮内瘤变中，其程度介于正常组织（神经内分泌分化细胞最多）和癌之间。
结论
前列腺癌前体中的神经内分泌分化可能在癌症发病机制中起作用，但目前只是推测。需要更好地评估神经内分泌分化的方法。
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