Delemarre F G, Simons P J, Drexhage H A
Department of Immunology, Erasmus University Rotterdam, The Netherlands.
Thyroid. 1996 Aug;6(4):369-77. doi: 10.1089/thy.1996.6.369.
In this short review we will first evaluate the histomorphological aspects of the human and spontaneous animal thyroid autoimmune diseases. These diseases include Hashimoto goiter, primary myxedema, Graves' disease, and the spontaneous forms of thyroiditis in the Bio Breeding (BB) rat, the nonobese diabetic (NOD) mouse, and the obese strain (OS) of chicken. Based on sequential histomorphological events in the animal models of thyroid autoimmune disease, a mechanism for the pathogenesis of thyroid autoimmune disease is proposed. Since one of the human thyroid autoimmune diseases, specifically Graves' disease, is often associated with ophthalmopathy, the histomorphological aspects of the ophthalmopathic process are also evaluated to consider its possible autoimmune character.
在这篇简短的综述中，我们将首先评估人类和自发性动物甲状腺自身免疫性疾病的组织形态学方面。这些疾病包括桥本甲状腺肿、原发性黏液性水肿、格雷夫斯病，以及生物繁殖（BB）大鼠、非肥胖糖尿病（NOD）小鼠和肥胖品系（OS）鸡的自发性甲状腺炎形式。基于甲状腺自身免疫性疾病动物模型中的连续组织形态学事件，提出了甲状腺自身免疫性疾病的发病机制。由于人类甲状腺自身免疫性疾病之一，特别是格雷夫斯病，常与眼病相关，因此我们也评估了眼病过程的组织形态学方面，以考虑其可能的自身免疫特性。
