Kitamura K, Taniguchi H, Yamaguchi T, Takahashi T
First Department of Surgery, Kyoto Prefectural University of Medicine, Japan.
Tohoku J Exp Med. 1996 Jun;179(2):93-100. doi: 10.1620/tjem.179.93.
The clinicopathological features of 31 young patients with early gastric cancer, defined as under 40 years of age, were reviewed retrospectively from hospital records between 1969 and 1993. The results were compared with those for 549 patients 40 years of age or older. Early gastric cancer was found in 36.0% of the younger patients with gastric cancers and in 36.3% of the older patients with those. The gender ratio of m/f was 1.21 for the younger patients and 2.37 for the older patients. The macroscopic characteristics of early gastric cancer for the younger patients were superficial depressed lesions and a larger tumor size. The distinguished histologic features of early gastric cancer for the younger patients were a diffuse type of cancer and infiltrative tumor growth with a scirrhous stroma. More extensive lymph node dissection was performed on the younger patients than on the older patients. The younger patients had a prognosis similar to that of the older patients. We conclude that early gastric cancer in young patients possesses histological aggressiveness, but those patients rather show a similar survival to older patients.
回顾性分析了1969年至1993年间医院记录中31例年龄在40岁以下的早期胃癌年轻患者的临床病理特征，并与549例40岁及以上患者的结果进行了比较。在年轻胃癌患者中，早期胃癌的检出率为36.0%，在老年胃癌患者中为36.3%。年轻患者的男女比例为1.21，老年患者为2.37。年轻患者早期胃癌的宏观特征为浅表凹陷性病变和肿瘤体积较大。年轻患者早期胃癌独特的组织学特征为弥漫型癌和伴有硬癌间质的浸润性肿瘤生长。年轻患者比老年患者接受了更广泛的淋巴结清扫。年轻患者的预后与老年患者相似。我们得出结论，年轻患者的早期胃癌具有组织学侵袭性，但这些患者的生存率与老年患者相似。
