Kitamura K, Yamaguchi T, Yamamoto K, Ichikawa D, Taniguchi H, Hagiwara A, Sawai K, Takahashi T
First Department of Surgery, Kyoto Prefectural University of Medicine, Japan.
Hepatogastroenterology. 1996 Sep-Oct;43(11):1273-80.
BACKGROUND/AIMS: Whether gastric cancer in young patients differs in any way from gastric cancer in older patients has been a controversial issue. This study was designed to determine the clinicopathological features of gastric cancer in young patients.
The clinicopathological features of 86 young patients with gastric cancer, defined as 39 years of age or younger, were reviewed retrospectively from hospital records between 1969 and 1993. They were then compared with 1134 middle-aged patients with gastric cancer between 40 and 69 years old.
The incidence of gastric cancer in young patients declined from 6.34% of all gastric cancer patients 20 years ago to 4.49% in the most recent decade. The histopathological findings for gastric cancer in young patients were aggressive features, including an undifferentiated type, a scirrhous type, and an infiltrating type (defined as infiltrating growth and an indistinct border from the surrounding tissues). There were no statistical differences in tumor staging and survival between the 2 groups.
Gastric cancer in young patients decreased in overall incidence, but possesses aggressive histopathological features different from older patients. Furthermore, the tumor staging and prognosis for young patients was similar to middle-aged patients.
背景/目的：年轻患者的胃癌与老年患者的胃癌是否存在差异一直是一个有争议的问题。本研究旨在确定年轻患者胃癌的临床病理特征。
回顾性分析了1969年至1993年间医院记录中86例年龄在39岁及以下的年轻胃癌患者的临床病理特征。然后将他们与1134例年龄在40至69岁之间的中年胃癌患者进行比较。
年轻患者胃癌的发病率从20年前占所有胃癌患者的6.34%下降到最近十年的4.49%。年轻患者胃癌的组织病理学表现为侵袭性特征，包括未分化型、硬癌型和浸润型（定义为浸润性生长且与周围组织边界不清）。两组之间的肿瘤分期和生存率无统计学差异。
年轻患者胃癌的总体发病率有所下降，但具有与老年患者不同的侵袭性组织病理学特征。此外，年轻患者的肿瘤分期和预后与中年患者相似。
