Remschmidt H, Mewe F u, Dauner I, Merschmann W
Pharmakopsychiatr Neuropsychopharmakol. 1977 Jan;10(1):1-9. doi: 10.1055/s-0028-1094511.
Starting with a brief review of literature about the application of Melleril (Thioridazine) in child psychiatry the authors report a double blind study with 26 children (23 boys and 3 girls at the age of 6 to 14). These children were admitted to clinical treatment because of several behavior disorders. Drug effects on psychomotor activity, concentration power and reactivity were measured by the d2-Test (Brickenkamp), by a tapping experiment, a psychomotor experimental (tracing) and experiments with the Vienna determination apparatus. As compared to the placebo group a statistically significant increase was found in the experimental group in the tapping experiment as well as in one stage of the concentration test. No difference between the groups could be noted in tracing and in the performance of the Vienna determination apparatus. It is suggested that the finding result from a different ability in visuo-motor information processing without or under the drug. Accordingly Melleril seems to advance performance in simply structured motor tasks, whereas complex choice reactions rather appear to be rendered more difficult under this medication.
作者首先简要回顾了有关甲硫达嗪（硫利达嗪）在儿童精神病学中应用的文献，然后报告了一项针对26名儿童（23名男孩和3名女孩，年龄在6至14岁之间）的双盲研究。这些儿童因多种行为障碍而接受临床治疗。通过d2测试（布里克坎普）、敲击实验、精神运动实验（追踪）以及使用维也纳测定仪进行的实验，来测量药物对精神运动活动、注意力集中能力和反应性的影响。与安慰剂组相比，实验组在敲击实验以及注意力测试的一个阶段中，发现有统计学意义的增加。在追踪实验和维也纳测定仪的表现方面，两组之间未发现差异。研究表明，这一结果源于在无药物或使用药物情况下视觉运动信息处理能力的不同。因此，甲硫达嗪似乎能提高简单结构运动任务的表现，而在这种药物作用下，复杂的选择反应似乎变得更加困难。
