Tan T W, Lee K M, Chua E J
Department of Therapeutic Radiology, Singapore General Hospital, Singapore.
Ann Acad Med Singap. 1996 May;25(3):363-6.
A retrospective analysis was done of 49 patients treated for testicular seminoma over a 15-year period between January 1980 and April 1995 at the Department of Therapeutic Radiology, Singapore General Hospital. Their mean age was 39 years and their median period of follow-up was 67 months. Using the Royal Marsden Staging classification, 35 (71.4%) were stage I, 10 (20.4%) were stage II, I (2%) was stage III, and 3 (6.1%) were stage IV. Five (10.2%) arose in undescended testes. Thirty-six patients were treated with inguinal orchidectomy and postoperative radiotherapy to the para-aortic and ipsilateral iliac nodes. Eight had para-aortic and bilateral iliac irradiation, and 2 had ipsilateral pelvic, para-aortic, mediastinal and supraclavicular lymph node irradiation. Six of the patients had, in addition, irradiation of the inguinal-scrotal area. Nine received both chemotherapy as well as radiotherapy. The median dose of radiation given was 30.67 Gy and where a boost was required, the median total tumour dose was 35.75 Gy. The actuarial relapse-free survival at 10 years was 88.9% and the actuarial overall survival at 10 years was also 88.9%. Long-term treatment toxicities were uncommon.
对1980年1月至1995年4月期间在新加坡总医院放射治疗科接受睾丸精原细胞瘤治疗的49例患者进行了回顾性分析。他们的平均年龄为39岁，中位随访期为67个月。采用皇家马斯登分期分类，I期35例（71.4%），II期10例（20.4%），III期1例（2%），IV期3例（6.1%）。5例（10.2%）发生于隐睾。36例患者接受腹股沟睾丸切除术及术后主动脉旁和同侧髂淋巴结放疗。8例接受主动脉旁和双侧髂部照射，2例接受同侧盆腔、主动脉旁、纵隔和锁骨上淋巴结照射。此外，6例患者还接受了腹股沟阴囊区照射。9例同时接受了化疗和放疗。给予的中位放射剂量为30.67 Gy，如需加强照射，中位总肿瘤剂量为35.75 Gy。10年的精算无复发生存率为88.9%，10年的精算总生存率也为88.9%。长期治疗毒性并不常见。
