Chen S Y, Burger R I, Reith M E
Department of Biomedical and Therapeutic Sciences, University of Illinois, College of Medicine, Peoria 61656, USA.
Brain Res. 1996 Aug 12;729(2):294-6.
Rats were implanted with dual dialysis probes, one in the ventral tegmental area, and another one ipsilateral in the nucleus accumbens. Infusion of cocaine (10, 100, 1000 mM) into the ventral tegmental area gradually increased extracellular dopamine to 164, 329 and 991% of baseline in the ventral tegmental area, but reduced dopamine to 76, 47 and 38% of baseline in the nucleus acumbens. These results are consistent with cocaine-induced feedback regulation of dopamine cell activity involving somatodendritic impulse regulating dopamine D2 autoreceptors.
给大鼠植入双透析探针，一个置于腹侧被盖区，另一个在同侧伏隔核。向腹侧被盖区注入可卡因（10、100、1000 mM），可使腹侧被盖区细胞外多巴胺逐渐增加至基线水平的164%、329%和991%，但使伏隔核中的多巴胺降至基线水平的76%、47%和38%。这些结果与可卡因诱导的多巴胺细胞活动的反馈调节一致，该调节涉及树突体冲动对多巴胺D2自身受体的调节。
