奥门氏综合征患者的选择性γ链T细胞受体基因重排：缺乏V-II亚组（Vγ9）转录本
Selective gamma-chain T-cell receptor gene rearrangements in a patient with Omenn's syndrome: absence of V-II subgroup (V gamma 9) transcripts.
作者信息
Mathioudakis G, Good R A, Chernajovsky Y, Day N K, Platsoucas C D
机构信息
Department of Immunology, M. D. Anderson Cancer Center, University of Texas, Houston, USA.
出版信息
Clin Diagn Lab Immunol. 1996 Sep;3(5):616-9. doi: 10.1128/cdli.3.5.616-619.1996.
Abstract
Only gamma-chain T-cell receptor transcripts utilizing V-1 subgroup gene segments were found in peripheral blood lymphocytes from a patient with Omenn's syndrome. gamma-Chain T-cell receptor transcripts utilizing the V gamma 9 (V-II subgroup) gene segment were absent in peripheral blood lymphocytes from this patient. V gamma 9 J gamma 1.2 C gamma 1 rearrangements are those primarily found in peripheral blood lymphocytes (70 to 85%) from normal donors.
摘要
在一名患有奥门氏综合征患者的外周血淋巴细胞中，仅发现利用V-1亚组基因片段的γ链T细胞受体转录本。该患者外周血淋巴细胞中不存在利用Vγ9（V-II亚组）基因片段的γ链T细胞受体转录本。Vγ9 Jγ1.2 Cγ1重排主要存在于正常供体的外周血淋巴细胞（70%至85%）中。
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本文引用的文献
1
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N Engl J Med. 1965 Aug 19;273:427-32. doi: 10.1056/NEJM196508192730806.
2
Preferential rearrangements of the V gamma I subgroup of the gamma-chain of the T-cell antigen receptor to J gamma 2C gamma 2 gene segments in peripheral blood lymphocyte transcripts from normal donors.来自正常供体的外周血淋巴细胞转录本中，T细胞抗原受体γ链的VγI亚组与Jγ2Cγ2基因片段的优先重排。
Scand J Immunol. 1993 Jul;38(1):31-6. doi: 10.1111/j.1365-3083.1993.tb01690.x.
3
Expansion of CD3+CD4-CD8- T cell population expressing high levels of IL-5 in Omenn's syndrome.奥门氏综合征中表达高水平白细胞介素-5的CD3⁺CD4⁻CD8⁻T细胞群体的扩增
Clin Exp Immunol. 1994 Jan;95(1):14-21. doi: 10.1111/j.1365-2249.1994.tb06008.x.
4
Inhibition of specific cell-mediated cytotoxicity by monoclonal antibodies to human T cell antigens.抗人T细胞抗原单克隆抗体对特异性细胞介导细胞毒性的抑制作用。
Proc Natl Acad Sci U S A. 1981 Jul;78(7):4500-4. doi: 10.1073/pnas.78.7.4500.
5
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Clin Immunol Immunopathol. 1980 Feb;15(2):245-50. doi: 10.1016/0090-1229(80)90035-5.
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The Omenn's syndrome: histological, immunohistochemical and ultrastructural evidence for a partial T cell deficiency evolving in an abnormal proliferation of T lymphocytes and S-100 +/T-6 + Langerhans-like cells.奥门氏综合征：T淋巴细胞和S-100+/T-6+朗格汉斯样细胞异常增殖过程中发生的部分T细胞缺陷的组织学、免疫组织化学及超微结构证据。
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J Exp Med. 1988 Aug 1;168(2):761-76. doi: 10.1084/jem.168.2.761.
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