Ruoslahti E
La Jolla Cancer Research Center, Burnham Institute, La Jolla, CA 92037, USA.
Glycobiology. 1996 Jul;6(5):489-92. doi: 10.1093/glycob/6.5.489.
The extracellular matrix of the adult brain tissue has a unique composition. The striking feature of this matrix is the prominence of lecticans, proteoglycans that contain a lectin domain and a hyaluronic acid-binding domain. Hyaluronic acid and tenascin family adhesive/anti-adhesive proteins are also abundant. Matrix proteins common in other tissues are nearly absent in adult brain. The brain extracellular matrix appears to have trophic effects on neuronal cells and affect neurite outgrowth. The unique composition of this matrix may be responsible for the resistance of brain tissue toward invasion by tumors of non-neuronal origin.
成人大脑组织的细胞外基质具有独特的组成。这种基质的显著特征是凝集素聚糖的突出，凝集素聚糖是一种包含凝集素结构域和透明质酸结合结构域的蛋白聚糖。透明质酸和腱生蛋白家族的黏附/抗黏附蛋白也很丰富。其他组织中常见的基质蛋白在成人大脑中几乎不存在。脑细胞外基质似乎对神经元细胞具有营养作用，并影响神经突的生长。这种基质的独特组成可能是脑组织对非神经源性肿瘤侵袭具有抗性的原因。
