黄素酶活性的模型系统。特定氢键对黄素13C和1H核磁共振的影响。

Model systems for flavoenzyme activity. The effects of specific hydrogen bonds on the 13C and 1H NMR of flavins.

作者信息

Niemz A, Rotello V M

机构信息

Department of Chemistry, University of Massachusetts, Amherst 01003, USA.

出版信息

J Mol Recognit. 1996 Mar-Apr;9(2):158-62. doi: 10.1002/(sici)1099-1352(199603)9:2<158::aid-jmr257>3.0.co;2-n.

DOI:10.1002/(sici)1099-1352(199603)9:2<158::aid-jmr257>3.0.co;2-n

PMID:8877808

Abstract

We have developed a family of receptors designed to bind flavin derivatives using specific hydrogen bond interactions. These synthetic host molecules provide a model for specific flavoenzyme-cofactor interactions, allowing isolation and observation of the effects of hydrogen bonding on flavin NMR. We describe here the use of one of these receptors to study the effects of hydrogen bonding to O(2), N(3), and O(4) on flavin 1H and 13C NMR.

摘要

我们开发了一类受体，旨在通过特定的氢键相互作用结合黄素衍生物。这些合成主体分子为黄素酶 - 辅因子的特异性相互作用提供了一个模型，能够分离并观察氢键对黄素核磁共振（NMR）的影响。我们在此描述了使用其中一种受体来研究与O(2)、N(3)和O(4)形成氢键对黄素1H和13C NMR的影响。