两种新型前列腺素和一种血栓素的鉴定。

The identification of two novel prostaglandins and a thromboxane.

作者信息

Cockerill A F, Mallen D N, Osborne D J, Boot J R, Dawson W

出版信息

Prostaglandins. 1977 Jun;13(6):1033-43. doi: 10.1016/0090-6980(77)90131-9.

Abstract

6,15-Dioxo-PGF1alpha, 6,15-dioxo-13,14-dihydro-PGF1alpha and 15-oxo-thromboxane B2 have been identified in incubates of ram seminal vesicle homogenates with added arachidonic acid or in the perfusate from sensitised challenged guinea pig lungs. These compounds are probably related to 6-oxo-PGF1alpha and thromboxane B2. The structures have been determined by gas chromatography mass spectrometry, following suitable chemical derivatisation.

摘要

在添加花生四烯酸的公羊精囊匀浆孵育物中，或在致敏激发的豚鼠肺灌注液中，已鉴定出6,15 - 二氧代 - PGF1α、6,15 - 二氧代 - 13,14 - 二氢 - PGF1α和15 - 氧代 - 血栓素B2。这些化合物可能与6 - 氧代 - PGF1α和血栓素B2有关。在进行适当的化学衍生化后，通过气相色谱 - 质谱法确定了其结构。