Kirschenbaum M A
Prostaglandins. 1977 Jun;13(6):1103-12. doi: 10.1016/0090-6980(77)90137-x.
It has been suggested that increased prostaglandin release may mediate the natriuresis seen during the administration of renal vasodilators. To further investigate this possibility, either acetylcholine (40 microgram/min) or bradykinin (5 microgram/min) was infused into the left renal artery of anesthetized dogs previously given an inhibitor of prostaglandin synthesis. During the infusion of either vasodilator drug in the prostaglandin-inhibited dogs, urinary sodium excretion increased to a similar degree as in a group of normal dogs with intact prostaglandin synthesis. These studies therefore do not confirm that prostaglandins play a significant role in the natriuresis of drug-induced vasodilatation.
有人提出，前列腺素释放增加可能介导肾血管扩张剂给药期间出现的利钠作用。为了进一步研究这种可能性，将乙酰胆碱（40微克/分钟）或缓激肽（5微克/分钟）注入先前给予前列腺素合成抑制剂的麻醉犬的左肾动脉。在前列腺素抑制的犬中注入任何一种血管扩张剂药物期间，尿钠排泄增加的程度与前列腺素合成完整的正常犬组相似。因此，这些研究并未证实前列腺素在药物诱导的血管扩张引起的利钠作用中起重要作用。
