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兔尿中前列腺素的放射免疫和生物学测定：高钠摄入时PGE2排泄减少。

Radioimmunological and biological measurement of prostaglandins in rabbit urine: decrease of PGE2 excretion at high NaCl intake.

作者信息

Scherer B, Siess W, Weber P C

出版信息

Prostaglandins. 1977 Jun;13(6):1127-39. doi: 10.1016/0090-6980(77)90139-3.

DOI:10.1016/0090-6980(77)90139-3
PMID:887801
Abstract

The estimation of prostaglandin (PG) E2 and of PGF2alpha by radioimmunoassay is described in detail. PGE2 was measured after conversion to either PGB2 or PGF2alpha and the results compared to bioassay. The methods were used to follow the excretion of PGE2 and PGF2alpha after salt loading in rabbits. A marked reduction of PGE2 levels was observed at high NaC1 intake, while PGF2alpha excretion remained unchanged.

摘要

详细描述了通过放射免疫测定法对前列腺素（PG）E2和PGF2α的测定。将PGE2转化为PGB2或PGF2α后进行测量，并将结果与生物测定法进行比较。这些方法用于追踪兔子盐负荷后PGE2和PGF2α的排泄情况。在高氯化钠摄入量时观察到PGE2水平显著降低，而PGF2α的排泄保持不变。

相似文献

1
Radioimmunological and biological measurement of prostaglandins in rabbit urine: decrease of PGE2 excretion at high NaCl intake.兔尿中前列腺素的放射免疫和生物学测定：高钠摄入时PGE2排泄减少。
Prostaglandins. 1977 Jun;13(6):1127-39. doi: 10.1016/0090-6980(77)90139-3.
2
The influence of dietary sodium on urinary prostaglandin excretion.
Acta Physiol Scand. 1978 May;103(1):100-6. doi: 10.1111/j.1748-1716.1978.tb06195.x.
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Prostaglandin (PG) analysis in urine of humans and rats by different radioimmunoassays: effect on PG-excretion by PG-synthetase inhibitors, laparotomy and furosemide.
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Radioimmunoassay measurement of prostaglandins E2 and F2alpha in human urine.
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Effect of sodium loading on the urinary excretion of prostaglandins E2 and F2 alpha in rats with hereditary diabetes insipidus (Brattleboro rats).钠负荷对遗传性尿崩症大鼠（布拉特洛维大鼠）前列腺素E2和F2α尿排泄的影响。
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Renal prostaglandins and sodium balance in the rabbit: lack of effect of aspirin-like drugs.
Acta Pharmacol Toxicol (Copenh). 1980 Jan;46(1):57-61. doi: 10.1111/j.1600-0773.1980.tb02420.x.
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Bartter's syndrome: contrasting patterns of prostaglandin excretion in children and adults.巴特综合征：儿童与成人前列腺素排泄的对比模式
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[Method for determining prostaglandins in urine].[尿液中前列腺素的测定方法]
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Sodium intake as a determinant of urinary prostaglandin excretion. Studies in the Brattleboro rat.钠摄入量作为尿前列腺素排泄的决定因素。对布拉德福德大鼠的研究。
Prostaglandins Leukot Med. 1986 Aug;23(2-3):239-47. doi: 10.1016/0262-1746(86)90191-5.

引用本文的文献

1
Dietary salt induces transcription of the prostaglandin transporter gene in renal collecting ducts.膳食盐可诱导肾集合管中前列腺素转运体基因的转录。
Am J Physiol Renal Physiol. 2008 Sep;295(3):F765-71. doi: 10.1152/ajprenal.00564.2007. Epub 2008 Jun 25.
2
Urinary prostaglandins in human neonates: relationship to kidney function and blood pressure.人类新生儿的尿前列腺素：与肾功能和血压的关系。
Klin Wochenschr. 1980 May 2;58(9):449-55. doi: 10.1007/BF01476799.
3
Sodium chloride as regulator of renal prostaglandin E2 production in patients with essential hypertension.
氯化钠作为原发性高血压患者肾前列腺素E2生成的调节剂。
Klin Wochenschr. 1982 Jun 1;60(11):579-81. doi: 10.1007/BF01724215.
4
Prostaglandin E2 excretion, urine flow and papillary osmolality during saline or dextrose infusion in the conscious rat.清醒大鼠输注生理盐水或葡萄糖期间的前列腺素E2排泄、尿流量及乳头渗透压
J Physiol. 1983 Mar;336:39-46. doi: 10.1113/jphysiol.1983.sp014564.
5
[Reduced urinary prostaglandin E2-excretion and diminished responsiveness of plasma renin activity in patients with essential hypertension (author's transl)].
Klin Wochenschr. 1979 Jun 1;57(11):567-73. doi: 10.1007/BF01491135.
6
Renal prostaglandins: relationship to the development of blood pressure and concentrating capacity in pre-term and full term healthy infants.肾前列腺素：与早产和足月健康婴儿血压及浓缩能力发育的关系
Eur J Pediatr. 1979;132(4):253-9. doi: 10.1007/BF00496848.
7
[Prostaglandins in cardiovascular and renal function. Biochemical, physiological and clinical findings (author's transl)].[前列腺素在心血管和肾功能中的作用。生化、生理及临床研究结果（作者译）]
Klin Wochenschr. 1979 May 3;57(9):425-44. doi: 10.1007/BF01477496.