大鼠中线创伤性脑损伤后小脑的细胞反应。
Cellular response in the cerebellum after midline traumatic brain injury in the rat.
作者信息
Mautes A E, Fukuda K, Noble L J
机构信息
Department of Neurosurgery, University of California, San Francisco, USA.
出版信息
Neurosci Lett. 1996 Aug 23;214(2-3):95-8. doi: 10.1016/0304-3940(96)12916-5.
PMID:8878092
Abstract
We evaluated the response of microglia and Purkinje cells in the cerebellum at 1, 2, 3, 7 and 10 days after a midline fluid percussion brain injury. There was marked activation of microglia and a significant loss of Purkinje cells in the vermis by 7 days postinjury. These findings emphasize the vulnerability of the cerebellum to midline traumatic brain injury.
摘要
我们评估了中线流体冲击性脑损伤后1天、2天、3天、7天和10天小脑内小胶质细胞和浦肯野细胞的反应。损伤后7天，小胶质细胞明显激活，蚓部浦肯野细胞显著丢失。这些发现强调了小脑对中线创伤性脑损伤的易损性。
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