Partonen T, Lönnqvist J
Department of Mental Health, National Public Health Institute, Helsinki, Finland.
Psychol Med. 1996 Sep;26(5):1075-80. doi: 10.1017/s003329170003539x.
In patients with winter seasonal affective disorder (SAD) the onset of a depressive episode is probably associated with the decreasing amount of light during the autumn. A highly predictable onset of a recurrent depressive episode with seasonal pattern provides a rationale for testing the efficacy of bright-light treatment as a preventive measure. Twelve out-patients with winter SAD were assigned to start bright light treatment either when they were well, or not to start it until the first symptoms of depression had already emerged. The severity of depressive symptoms was prospectively rated for a parallel randomized comparison. Bright light given well in advance of the emerging symptoms prevented a depressive episode. Clinical remission was significantly more frequent in the former subgroup of the patients in January and in March. To sum up, bright light can be successfully administered as prophylactic treatment for the prevention of winter SAD.
在患有冬季季节性情感障碍（SAD）的患者中，抑郁发作可能与秋季光照量减少有关。具有季节性模式的复发性抑郁发作高度可预测的发作情况，为测试强光治疗作为预防措施的疗效提供了理论依据。12名患有冬季SAD的门诊患者被分配为，要么在病情良好时开始强光治疗，要么直到已经出现抑郁的最初症状才开始治疗。对抑郁症状的严重程度进行前瞻性评估，以进行平行随机比较。在症状出现之前提前给予强光可预防抑郁发作。在1月和3月，前一组患者的临床缓解明显更为常见。总之，强光可以成功地作为预防冬季SAD的预防性治疗。
