戊四氮的突触机制：对氯电导的选择性

Synaptic mechanism of pentylenetetrazole: selectivity for chloride conductance.

作者信息

Pellmar T C, Wilson W A

出版信息

Science. 1977 Aug 26;197(4306):912-4. doi: 10.1126/science.887932.

Abstract

In the neurons of Aplysia californica pentylenetetrazole (2 millimolar) greatly reduced chloride-dependent responses to the iontophoresis of putative transmitters. At the same concentration, pentylenetetrazole caused less attenuation of the other iontophoretic responses and had minimal membrane effects. Several convulsants have been observed to have a similar selectivity for the chloride conductance. A common mechanism of convulsant action--reduction of transmitter-induced chloride conductances--is hypothesized.

摘要

在加州海兔的神经元中，戊四氮（2毫摩尔）极大地降低了对假定递质离子电渗的氯离子依赖性反应。在相同浓度下，戊四氮对其他离子电渗反应的衰减较小，且对膜的影响最小。已观察到几种惊厥剂对氯离子电导具有类似的选择性。据此推测出惊厥剂作用的一种常见机制——降低递质诱导的氯离子电导。