Pellmar T C, Wilson W A
Brain Res. 1977 Nov 4;136(1):89-101. doi: 10.1016/0006-8993(77)90134-2.
The effect of penicillin on neurons of Aplysia californica was studied using drug concentrations which would be convulsant in mammalian nervous systems. Iontophoretic responses were elicited by the application of acetylcholine, dopamine, gamma-aminobutyric acid and serotonin. Low concentrations of penicillin (2 mM) consistently and reversibly reduced the chloride-dependent hyperpolarizing responses by approximately 70%, regardless of the transmitter required to evoke them. The short depolarizing responses which are sodium sensitive are slightly reduced by a much higher (10 mM) concentration. The extent of the reduction of the excitatory response varied with the transmitter. The slow sodium-dependent depolarizations and the slow potassium-dependent hyperpolarizations were unaffected by the concentrations of penicillin used. The possibility that the convulsant effect of penicillin is due to interference with membrane conductance to chloride is discussed.
利用在哺乳动物神经系统中会引起惊厥的药物浓度，研究了青霉素对加州海兔神经元的影响。通过施加乙酰胆碱、多巴胺、γ-氨基丁酸和血清素引发离子电泳反应。低浓度的青霉素（2 mM）持续且可逆地使氯离子依赖性超极化反应降低约70%，无论引发这些反应所需的递质是什么。对钠敏感的短暂去极化反应在高得多的浓度（10 mM）下略有降低。兴奋性反应的降低程度因递质而异。缓慢的钠依赖性去极化和缓慢的钾依赖性超极化不受所用青霉素浓度的影响。讨论了青霉素的惊厥作用可能是由于干扰了对氯离子的膜电导。
