Gondos B, Byskov A G, Hansen J L
Sansum Medical Research Foundation, Santa Barbara, CA 93105, USA.
Ann Clin Lab Sci. 1996 Sep-Oct;26(5):421-5.
Meiotic division begins the process of spermatogenic maturation leading to sperm formation. In contrast to the ovary, in which meiosis is initiated early in development, onset of meiosis in the testis is delayed until the time of puberty. An assay procedure was utilized to evaluate factors responsible for the activation and prevention of meiosis in the developing rabbit testis. Testicular specimens from postnatal rabbits at different ages were used to determine if meiosis-activating substance (MAS) activity and meiosis-preventing substance (MPS) activity could be demonstrated prior to the onset of spermatogenesis. An in vitro system in which undifferentiated gonads from 11.5 day old mouse fetuses are cultured in test and control media was employed. The findings indicate that MAS activity is associated with the onset of spermatogenesis and is also present shortly after birth. Activity of MPS is present throughout much of the prespermatogenic period, with a decline to reach low levels at the onset of spermatogenesis.
减数分裂开启了精子发生成熟过程，最终形成精子。与卵巢不同，卵巢中的减数分裂在发育早期就开始了，而睾丸中的减数分裂则延迟到青春期。采用一种检测方法来评估发育中的兔睾丸中负责激活和阻止减数分裂的因素。使用来自不同年龄新生兔的睾丸标本，以确定在精子发生开始之前是否能检测到减数分裂激活物质（MAS）活性和减数分裂阻止物质（MPS）活性。采用一种体外系统，将11.5日龄小鼠胎儿的未分化性腺在试验培养基和对照培养基中培养。研究结果表明，MAS活性与精子发生的开始有关，并且在出生后不久也会出现。MPS活性在精子发生前期的大部分时间都存在，在精子发生开始时下降至低水平。
