Wasserstein P H, Honig L S
Dept of Neurology and Neurological Sciences, Stanford University School of Medicine, CA, USA.
Bone Marrow Transplant. 1996 Sep;18(3):649-50.
Cyclosporine has been associated with various neurological side-effects including postural tremor, seizures, headaches, encephalopathy, cortical blindness, and visual hallucinations. We describe here two patients who developed parkinsonism, with rest tremor and bradykinesia, after receiving cyclosporin A following allogeneic bone marrow transplantation. The patients did not have pre-existing neurological disorders, and had not received significant amounts of dopamine-blocking drugs. One patient improved markedly with Sinemet (carbidopa-levodopa), while the other (who did not tolerate Sinemet) improved with decrease in cyclosporine dosage. The relation of the parkinsonian symptoms to cyclosporine therapy and lack of other evident causes for the symptoms, suggests that parkinsonism may be an occasional consequence of cyclosporine.
环孢素与多种神经系统副作用相关，包括姿势性震颤、癫痫发作、头痛、脑病、皮质盲和视幻觉。我们在此描述两名在接受异基因骨髓移植后使用环孢素A后出现帕金森综合征的患者，表现为静止性震颤和运动迟缓。这两名患者既往没有神经系统疾病，也未使用过大量多巴胺阻断药物。一名患者使用息宁（卡比多巴-左旋多巴）后明显改善，而另一名患者（不能耐受息宁）在减少环孢素剂量后病情改善。帕金森综合征症状与环孢素治疗的关系以及缺乏其他明显病因，提示帕金森综合征可能是环孢素偶尔导致的后果。
