Moreau P, Méchinaud F, Mahé B, Le Tortorec S, Rapp M J, Maisonneuve H, Harousseau J L, Milpied N
Haematology Department, CHU Hôtel Dieu, Nantes, France.
Bone Marrow Transplant. 1996 Sep;18(3):665-7.
Two patients with high-grade disseminated non-Hodgkin's lymphoma relapsed 3 and 7 months respectively after high-dose chemotherapy and autologous BMT performed in first complete remission. Both patients had an HLA-identical sibling and received an allogeneic BMT 5 and 10 months after autologous BMT, after conditioning with fractionated 12 Gy total body irradiation plus cyclophosphamide. They both are alive and well, with a Karnofsky score of 100%, 15 and 27 months after allogeneic BMT. For selected patients with HLA-identical siblings and good performance status who relapse after autologous transplantation for high-grade non-Hodgkin's lymphoma, allogeneic BMT may be an option.
两名高度播散性非霍奇金淋巴瘤患者在首次完全缓解后分别接受了大剂量化疗和自体骨髓移植，3个月和7个月后复发。两名患者均有HLA配型相同的同胞，并在自体骨髓移植后5个月和10个月接受了异基因骨髓移植，预处理采用分次全身照射12 Gy加环磷酰胺。异基因骨髓移植后15个月和27个月，他们均存活且状况良好，卡氏评分100%。对于选定的有HLA配型相同的同胞且身体状况良好、在自体移植治疗高度非霍奇金淋巴瘤后复发的患者，异基因骨髓移植可能是一种选择。
