异基因骨髓移植治疗慢性淋巴细胞白血病后的移植物抗白血病效应
Graft-versus-leukemia effect after allogeneic bone marrow transplantation for chronic lymphocytic leukemia.
作者信息
Rondón G, Giralt S, Huh Y, Khouri I, Andersson B, Andreeff M, Champlin R
机构信息
Department of Hematology, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
出版信息
Bone Marrow Transplant. 1996 Sep;18(3):669-72.
PMID:8879640
Abstract
We report the case of a patient with chronic lymphocytic leukemia (CLL) with persistent lymphocytosis and lymphadenopathy after allogeneic bone marrow transplantation (BMT). After receiving a donor lymphocyte infusion on day 87 he achieved complete remission upon development of chronic graft-versus-host disease, suggesting that a graft-versus-leukemia effect is operative in this malignancy.
摘要
我们报告了1例慢性淋巴细胞白血病（CLL）患者，该患者在异基因骨髓移植（BMT）后出现持续性淋巴细胞增多和淋巴结病。在第87天接受供体淋巴细胞输注后，随着慢性移植物抗宿主病的出现，他实现了完全缓解，这表明移植物抗白血病效应在这种恶性肿瘤中起作用。
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