Kikuta A, Suzuki H
Department of Pediatrics, Fukushima Medical College, Japan.
Fukushima J Med Sci. 1993 Dec;39(2):95-9.
Allogeneic bone marrow transplantation (BMT) offers the hope of curing heretofore untreatable disease. Graft-versus-host disease (GVHD) is a complication of this medical progress which impedes application of marrow grafting a wider range of hematologic disorders. This report describes the clinical and pathologic features of GVHD and presents the clinical grading system for acute GVHD based on degree of target organ involvement. We report an acute lymphoblastic leukemia (ALL) patient relapsed after allogeneic BMT, who received an infusion of donor buffy coat and achieved complete remission of ALL with GVHD. This finding may be due to graft-versus-leukemia effect.
异基因骨髓移植（BMT）为治愈此前无法治疗的疾病带来了希望。移植物抗宿主病（GVHD）是这一医学进展的一种并发症，它阻碍了骨髓移植在更广泛的血液系统疾病中的应用。本报告描述了GVHD的临床和病理特征，并提出了基于靶器官受累程度的急性GVHD临床分级系统。我们报告了1例急性淋巴细胞白血病（ALL）患者，在异基因BMT后复发，接受供体白膜层输注后，ALL完全缓解并发生了GVHD。这一发现可能归因于移植物抗白血病效应。
