Ito J, Araki A, Tanaka H, Tasaki T, Cho K, Yamazaki R
Department of Pediatrics, Asahikawa Habilitation Center for Disabled Children, Hokkaido, Japan.
Brain Dev. 1996 Jul-Aug;18(4):299-303. doi: 10.1016/0387-7604(96)00006-x.
We studied the histopathology of spastic muscles in patients with spastic cerebral palsy using specimens obtained from the gastrocnemius muscles during orthopedic operations. Though there was no disease-specific abnormality, we found changes in fiber type distribution, i.e., type-1 fiber predominance and type-2B fiber deficiency. These changes were not found in the patient with brain infarction at age 1 year 5 months. Variation in fiber size, especially in type-1 fibers, was also detected in older patients and at the more severely affected sides. We speculated that the influence on the spinal motor unit from upper motor cortex might be applicable to the muscle histological findings and the time of the onset of the brain damage might be important.
我们使用在骨科手术中从腓肠肌获取的标本，研究了痉挛性脑瘫患者痉挛肌肉的组织病理学。尽管没有疾病特异性异常，但我们发现了纤维类型分布的变化，即1型纤维占优势和2B型纤维缺乏。在1岁5个月的脑梗死患者中未发现这些变化。在年龄较大的患者以及受影响更严重的一侧也检测到了纤维大小的变化，尤其是1型纤维。我们推测，上运动皮层对脊髓运动单位的影响可能适用于肌肉组织学发现，并且脑损伤的发病时间可能很重要。
