North R A
Glaxo Institute for Molecular Biology, Geneva, Switzerland.
Ciba Found Symp. 1996;198:91-105; discussion 105-9. doi: 10.1002/9780470514900.ch5.
Three classes of ligand-gated ion channels are defined by their molecular architecture. The first embraces nicotinic, 5-HT3, glycine and GABA receptors. The second class contains the glutamate receptors-AMPA, kainate and NMDA types. The third class is the P2X receptors for ATP. Current knowledge of the structure of these channels is reviewed, and set beside what is known of their basic functional properties. The aim of this paper is to consider how our more complete understanding of the first two classes of channels might be helpful in forming a molecular picture of P2X receptor function.
三类配体门控离子通道是根据其分子结构来定义的。第一类包括烟碱型、5-羟色胺3型、甘氨酸和γ-氨基丁酸受体。第二类包含谷氨酸受体——α-氨基-3-羟基-5-甲基-4-异恶唑丙酸（AMPA）型、海人藻酸型和N-甲基-D-天冬氨酸（NMDA）型。第三类是ATP的P2X受体。本文回顾了这些通道结构的现有知识，并将其与已知的基本功能特性放在一起进行阐述。本文的目的是探讨我们对前两类通道更全面的理解如何有助于构建P2X受体功能的分子图景。
