Egan Terrance M, Samways Damien S K, Li Zhiyuan
Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 S. Grand Boulevard, St. Louis, MO 63104, USA.
Pflugers Arch. 2006 Aug;452(5):501-12. doi: 10.1007/s00424-006-0078-1. Epub 2006 May 13.
The P2X receptor is the baby brother of the ligand-gated ion channel super-family. An understanding of its role in human physiology is still developing, and no one truly knows how it works to transport ions across the membrane. In this study, we review some aspects of P2X channel biophysics, concentrating on ion permeation and gating. P2X channels transport both small and large cations and anions across cell membranes in a manner that depends on both the subunit composition of the receptor and the experimental conditions. We describe the pore properties of wild-type receptors and use the altered phenotypes of mutant receptors to point the way towards a structural model of the pore.
P2X受体是配体门控离子通道超家族中的小成员。对其在人体生理学中作用的理解仍在不断发展，目前还没有人真正了解它是如何跨膜转运离子的。在本研究中，我们回顾了P2X通道生物物理学的一些方面，重点关注离子通透和门控。P2X通道以一种依赖于受体亚基组成和实验条件的方式跨细胞膜转运小阳离子和大阳离子以及阴离子。我们描述了野生型受体的孔道特性，并利用突变受体的改变表型来指向孔道结构模型的方向。
