Haseman M K, Reed N L, Rosenthal S A
Department of Nuclear Medicine, Sutter General Hospital, Sacramento, California 95816, USA.
Clin Nucl Med. 1996 Sep;21(9):704-13. doi: 10.1097/00003072-199609000-00007.
The utility of monoclonal antibody (MAb) imaging for detection of occult recurrent prostate cancer was investigated in 14 patients with elevated serum prostate-specific antigen at least 3 months after therapy. All were imaged with capromab pendetide (CYT-356) and subsequently had biopsies of the prostate bed. Ten also had PET scans with F-18 fluorodeoxyglucose. Ten MAb scans were positive for tumor in the prostate bed and eight showed lymph node metastases. Six of the seven patients with positive biopsies had positive MAb scans, one had a negative scan. Three of the seven patients with negative biopsies had negative MAb scans, four had positive scans. Of the six patients with positive biopsies who had PET scans, one was positive, five were negative. Two of four patients with negative biopsies had negative positron emission tomography scans, two were positive. MAb imaging is superior to PET scan for identifying recurrent disease in the prostate bed. Assuming no false-negative biopsies, the positive predictive values for MAb and PET scan are 60% and 33%, negative predictive values are 75% and 29% and sensitivities are 86% and 17%. Additional investigation is necessary to determine if MAb uptake in lymph nodes is predictive of metastatic disease.
对14例治疗后至少3个月血清前列腺特异性抗原升高的患者，研究了单克隆抗体（MAb）成像检测隐匿性复发性前列腺癌的效用。所有患者均接受卡普单抗（CYT - 356）成像，随后对前列腺床进行活检。其中10例患者还进行了F - 18氟脱氧葡萄糖PET扫描。10例MAb扫描显示前列腺床有肿瘤阳性，8例显示有淋巴结转移。7例活检阳性的患者中，6例MAb扫描阳性，1例扫描阴性。7例活检阴性的患者中，3例MAb扫描阴性，4例扫描阳性。6例活检阳性且进行了PET扫描的患者中，1例PET扫描阳性，5例阴性。4例活检阴性的患者中，2例正电子发射断层扫描阴性，2例阳性。在识别前列腺床复发性疾病方面，MAb成像优于PET扫描。假设活检无假阴性，MAb和PET扫描的阳性预测值分别为60%和33%，阴性预测值分别为75%和29%，敏感性分别为86%和17%。需要进一步研究以确定淋巴结中MAb摄取是否可预测转移性疾病。
